shantanu

Osteoarthritis (OA) is associated with multiple and overlapping aetiologies. IL-1β is produced by stressed tissue and known to aggravate disease pathologies. We selected 10 patients with elevated IL-1β in their synovial fluids (SF). We hypothesized IL-1β as nodal-point connecting different pathologies. IL-1β was higher in all meniscal tear (MT) patients perhaps as the earliest response to injury. [...]

Osteoarthritis (OA), a degenerative disease, is associated with reduced quality of life and amounts to enormous familial and social burden (1). OA pathology revolves around altered or impaired cytokine signalling (2) particularly IL-1β and TNF-α, leading to synovitis, an inflammatory condition, which destabilizes the process of cartilage remodelling leading to cartilage loss. Cartilage being aneural and [...]

Meniscal tear is thought to play a crucial role in onset as well as progression of arthritis. However, role of cytokine response to meniscal injury and resulting inflammation is not clearly understood. Because synovial fluid is juxtaposed to cartilage and serves as a biological connection between chondrocytes and synoviocytes, we chose synovial fluid analysis to ascertain biochemical response associated [...]

The clinical and radiological results of 50 consecutive acetabular reconstructions in 48 patients using impaction grafting have been retrospectively reviewed. A 1:1 mixture of frozen, ground irradiated bone graft and Apapore 60, a synthetic bone graft substitute, was used in all cases. There were 13 complex primary and 37 revision procedures with a mean follow-up of five years (3.4 to [...]

The inflammatory nature of synovial fluid (SF) of varying grade osteoarthritis (OA) patients was estimated by measuring pro-inflammatory factors and through a unique cell-challenge experiment. SF samples were collected from six OA and one non-OA patient. Download

The patients with healed severe progressive tubercular kyphosis may develop late‑onset paraplegia. A particular subgroup of these children (Type IB progression) may benefit from the management principles of congenital kyphosis. Self‑correction may be observed by selective continued growth of anterior vertebral epiphyseal end‑plates over the posterior fused mass. We report a series of cases with posterior fusion of [...]