Antioxidant Status In Synovial Fluid From Osteoarthritis Patients: A Pilot Study In Indian Demography
Crucial role of reactive oxygen species (ROS) in the progression Osteoarthritis (OA) pathogenesis has been endorsed several times though its exact mechanism remains unclear. Oxidative stress is known to instigate classical stress factors such as cytokines, [...]
Glycosaminoglycan In Synovial Fluid Of Osteoarthritis Patients Validates Kellgren-Lawrence Score As A Useful Indicator For Disease Progression And Cartilage Degradation
Cartilage is a marvel design, which handles a remarkable pressure in weight bearing joints yet facilitates resilient movement. Osteoarthritis (OA) is a disease characterised by progressive degeneration of cartilage, which is a dual result of [...]
IL-1β in synovial fluid potentially modulates multiple joint tissue pathologies leading to inflammation and accelerates cartilage degeneration
Osteoarthritis (OA) is associated with multiple and overlapping aetiologies. IL-1β is produced by stressed tissue and known to aggravate disease pathologies. We selected 10 patients with elevated IL-1β in their synovial fluids (SF). We hypothesized [...]
Interplay of Interleukin -1β, Nitric Oxide and Glycosaminoglycan in Synovial fluid obtained from Total knee replacement Patients may explain erosive Osteoarthritis
Osteoarthritis (OA), a degenerative disease, is associated with reduced quality of life and amounts to enormous familial and social burden (1). OA pathology revolves around altered or impaired cytokine signalling (2) particularly IL-1β and TNF-α, [...]
Meniscal tear as potential steering factor for inflammation may aggravate arthritis: two case reports
Meniscal tear is thought to play a crucial role in onset as well as progression of arthritis. However, role of cytokine response to meniscal injury and resulting inflammation is not clearly understood. Because synovial fluid is juxtaposed [...]
Impaction grafting of the acetabulum with a mixture of frozen, ground irradiated bone graft and porous synthetic bone substitute
The clinical and radiological results of 50 consecutive acetabular reconstructions in 48 patients using impaction grafting have been retrospectively reviewed. A 1:1 mixture of frozen, ground irradiated bone graft and Apapore 60, a synthetic bone graft substitute, [...]
Inflammatory response of cultured rat synoviocytes challenged with synovial fluid from osteoarthritis patients correlates with their radiographic grading
The inflammatory nature of synovial fluid (SF) of varying grade osteoarthritis (OA) patients was estimated by measuring pro-inflammatory factors and through a unique cell-challenge experiment. SF samples were collected from six OA and one non-OA patient. Download
Short term analysis of healed post‑tubercular kyphosis in younger children based on principles of congenital kyphosis
The patients with healed severe progressive tubercular kyphosis may develop late‑onset paraplegia. A particular subgroup of these children (Type IB progression) may benefit from the management principles of congenital kyphosis. Self‑correction may be observed by selective [...]