Cartilage is a marvel design, which handles a remarkable pressure in weight bearing joints yet facilitates resilient movement. Osteoarthritis (OA) is a disease characterised by progressive degeneration of cartilage, which is a dual result of inflammation and associated molecular damage. In recent years, use of several biochemical-markers has been emphasized, which provide pathology specific information. Being a degeneration product of cartilage matrix, glycosaminoglycan (GAG) has a merit as direct measure of cartilage degenerative changes. However, invasive nature and associated cross-talk explaining multidimensional role of these markers always limit its prognostic value for disease diagnosis. On the other side, most of the Orthopaedic Clinicians use Kellgren-Lawrence Score (KL) as a metric for OA diagnosis and progression, giving weightage to Joint Space Narrowing (JSN) and Osteophyte formation.
